1920x1080 Slide Master Template Dimensions - Any Issues to Be Aware of???

Are there any problematic issues to be aware of in creating SL360 Slide Master templates with 1920x1080 pixel dimensions (instead of the tiny default settings)? 

Only concerned with landscape layout responsiveness (no portrait mode) and everything "seems" to preview perfectly. 

Has anyone ever run into issues with larger 1920x1080 slide masters that I should be aware of prior to building more advanced layouts at that scale? I'm hoping that by using the Modern HTML 5 only player it can be done very seamlessly. Any thoughts, comments or suggestions are greatly appreciated. 

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