Accessibility best practices for courses with narration

Working on my first Storyline course... and wondering what are some good accessibility practices if it has narration throughout? Does it make sense to rework the tab order for screen readers if the narration covers the content? I will apply alt text to images and we're planning on closed captions for the script. If you've had similar experience with this, I'd love to hear how you approached this.

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Nicole Legault