If the guide is used as a reference, and the "interactions" are merely links between content, I think it'd be better to keep the source in Word and distribute it as a PDF. That's simple to update and share, especially since (I'm assuming) more people have a license for MS Word than for Articulate 360. And I think more people would already be comfortable with navigating and searching a PDF.
If you're looking to turn the guide into an eLearning, there are samples on the Forum of all sorts of interactions. But I doubt there's any one template that would work for all guides. The design and functionality should be developed based on the content.
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What kind of "interactive" options do you want?
If the guide is used as a reference, and the "interactions" are merely links between content, I think it'd be better to keep the source in Word and distribute it as a PDF. That's simple to update and share, especially since (I'm assuming) more people have a license for MS Word than for Articulate 360. And I think more people would already be comfortable with navigating and searching a PDF.
If you're looking to turn the guide into an eLearning, there are samples on the Forum of all sorts of interactions. But I doubt there's any one template that would work for all guides. The design and functionality should be developed based on the content.