Build a Categorization Quiz that is Accessible

Hi Scott.  Thanks for the suggestions!  I am coming around to something almost exactly like what you suggested in your second option.  Tinkering this morning, I discovered that you can apply button sets to the answer choices in multiple response questions, so you can make it so the user can only chose one of the category responses for any given row (symptom = row, in this case).  And, as you said, if you put a good name on each answer choice, that should work for screen readers. 

I also discovered that you can give a long name on the answer choices but use formatting to shrink elements of it for sighted users.  So, in your example, I might use "Symptom 1, Acute" as the label for the first answer choice, but make "Symptom 1" 6pt and "Acute" 12 pt with a manual line break in between.  Screen reader users would still hear the full title, but sighted users would probably just see "Acute" in the row for Symptom 1 and not notice the smaller first part of the label.  I will try to build an example in the next day or so and post it here for comment.

Your method one had also occurred to me but, as you point out, would take a lot of slides.

I wonder if I could give row-based feedback on Option 2 based on the answer state and embed it in the "incorrect" layer.... 

Again, I really appreciate your suggestions!  It helps to bounce ideas off of others.