Course File Size - How big is too Big

I just lived same situation. Multiple times i couldn't published my course. I cleaned my cache files and fixed registry files with a tool like CCleaner and closed all of the softwares that use RAM. Then i realized that the folder i use was in Local Drive D: which has not much free space. So i changed the published folder to Local Drive C:... So i'm not sure about the solution but it works for me after multiple tries. I think when you have a big Storyline file than it should be much better to use a Local Drive with more space and have more RAM...