I haven't seen this issue addressed yet so I am curious if this is the first you have heard of it?
Accessibility issue: Screen readers are not accounting for the change in the order of the answer choices when the "answer shuffle" is turned on in Storyline. This does not impact question shuffle, only answer shuffle. Please turn off the answer shuffle to resolve the issue. This also does not seem to be an issue in Rise, only Storyline. [image taken from a learner's screen]
To replicate: simply create a question with multiple choice. Set it to shuffle answers, enable screen reader, view in Review, refresh/clear cache, and see that the screen reader text does not update with each reload or the shuffled answer order....thus causing an issue for screen reader dependent audiences to inadvertently select the incorrect response.