Is it possible to easily highlight an area of screen and grey out the rest?

Hi All

Is there an easy way to highlight a section of the screen, in video or just normally, and grey out the rest?

Camtasia does it (it's called a spotlight call out) like this http://youtu.be/QirMx4B3Aq8

Any help gratefully received. If I have missed the obvious please do feel free to call me names.

Thanks

Andy

 

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