Loosing Triggers

Has anyone had the issue with randomly loosing triggers.  I have a rather large course (40+ scenes with 246 slides) and randomly my triggers will disappear or change.  Most frequently my triggers that I setup for my next button will change from the moving to the slide I set it to, to moving to the next slide, which is not right at all.  Has anyone else experienced this and possibly found a solution?  In desperate need of some assistance. 

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